Variations in the genes for human paraoxanases (PON1, PON2, and PON3) on the long arm of chromosome 7 may play a role in sporadic amyotrophic lateral sclerosis (ALS aka Lou Gehrig’s Disease). The superoxide dismutase (SOD1) gene and Hox family of genes have previously been implicated in familial, or inherited, ALS but they account for a small percentage of overall cases of ALS.
PON genes help to detoxify organophosphate insecticides and nerve gas agents and thus could explain why Gulf War veterans have a higher risk of ALS. They may act by interacting with exposure to nerve gas or the wide range of pesticides used in the Gulf War, including OP, methyl carbamate, organochlorine, pyrethroid, and DEET pesticides. Genetically susceptible soldiers could be more likely to develop ALS if they were exposed to these chemicals.
For more information on veterans, their experience after combat, and post-traumatic stress disorder, visit PTSD Combat – a blog that was featured at Genetics and Health earlier this year.
EurekAlert, July 5, 2006
Photo credit: BBC News Online
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